The goal of any drug delivery system is to provide a therapeutic amount of the drug to the proper site in the body to achieve promptly, and then maintain, the desired drug concentration. That is, the drug delivery system should deliver drug at a rate dictated by the needs of the body over the period of treatment. The oral route remains the most acceptable route of drug administration because of low cost of therapy, ease of administration, and improved patient compliance. The floating drug delivery system with respect to various characteristics is essential to precisely control dosage form behavior and ensure batch-to-batch uniformity. The Floating tablets were prepared by conventional wet granulation, method by using different concentration of different polymer within the formulation. The objective of present study is to prepare and evaluate sustained release floating tablet of omeprazole by evaluation and optimizes with marketed product. Omeprazole are used to relive acid indigestion, upset stomach, sour stomach, and heartburn. It has rapid onset of action and they are free from side effects because they act locally in the stomach without being absorbed in the gastrointestinal mucosa and are most appropriate for rapid relief of gastric discomfort for a short period of time. The present work was, therefore, planned to design a floating tablet of omeprazole. It was intended that the immediate release of the formulation would retain the advantage of quick onset of action.
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